Long Lab

Publications

2024

Uttley K*, Juellig HJ*, De Angelis C, Bengani H, Long HK (* co-first author). Neanderthal-derived variants shape craniofacial enhancer activity at a human disease locus. bioRxiv (2024).

2023

Review : Chen LF, Long HK. Topology regulatory elements: From shaping genome architecture to gene regulation. Current Opinion in Structural Biology 83:102723 (2023).

Chen LF*, Long HK*, Park M, Swigut T, Boettiger AN, Wysocka J (* co-first author). Structural elements facilitate extreme long-range gene regulation at a human disease locus. Molecular Cell 4;83(9):1446-1461.e6 (2023).

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2020

Long HK, Osterwalder M, Welsh IC, Hansen K, Davies JOJ, Liu Y, Koska M, Adams AT, Aho R, Arora N, Ikeda K, Williams R, Sauka-Spengler T, Porteus M, Mohun T, Dickel DE, Swigut T, Hughes JR, Higgs DR, Visel A, Selleri L, Wysocka J. Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder. Cell Stem Cell 27, 1–19 (2020).

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Samuels BD, Aho R, Brinkley JF, Bugacov A, Feingold E, Fisher S, Gonzalez-Reiche AS, Hacia JG, Hallgrimsson B, Hansen K, Harris MP, Hochheiser H, Ho T, Holmes G, Hooper JE, Wang Jabs E, Jones KL, Kesselman C, Klein OD, Leslie EJ, Li H, Liao EC, Long HK, Lu N, Maas RL, Marazita ML, Mohammed J, Prescott S, Schuler R, Selleri L, Spritz RA,  Swigut T, van Bakel H, Visel A, Welsh I, Williams C, Williams TJ, Wysocka J, Yuan Y, and Chai Y. FaceBase 3: A FAIR Resource for Craniofacial and Dental Research. Development 147(18) (2020).

2019

Greenberg RS, Long HK, Swigut T, and Wysocka J. Single amino acid change underlies distinct roles of H2A.Z subtypes in human syndrome. Cell 178 (6): 1421-1436.e24 (2019).

Bowen ME, McClendon J, Long HK, Sorayya A, Van Nostrand JL, Wysocka J, Attardi LD. The Spatiotemporal Pattern and Intensity of p53 Activation Dictates Phenotypic Diversity in p53-Driven Developmental Syndromes. Developmental Cell S1534-5807(19)30387-9 (2019).

2018

Book Chapter : Long HK, Rose NR, Blackledge NP, Klose RJ. Biochemical Identification of Nonmethylated DNA by BioCAP-Seq. Methods in Molecular Biology, CpG Islands. 1766:15-29 (2018).

2017

Brown DA*, Di Cerbo V*, Feldmann A, Ahn J, Ito S, Blackledge NP, Nakayama M, McClellan M, Dimitrova E, Turberfield AH, Long HK, King HW, Kriaucionis S, Schermelleh L, Kutateladze TG, Koseki H, Klose RJ (* co-first author). The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin. Cell Reports 20(10): 2313–2327 (2017).

2016

Review : Long HK*, Prescott SL*, Wysocka J (* co-first author). Ever-Changing Landscapes: Transcriptional Enhancers in Development and Evolution. Cell 167(5): 1170–1187 (2016).

Ernst C, Pike J, Aitken SJ, Long HK, Eling N, Stojic L, Connor F, Rayner TF, Lukk M, Klose RJ, Kutter C, Odom DT. Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis. eLife 10.7554/eLife.20235 (2016).

Long HK, King HW, Patient RK, Odom DT and Klose RJ. Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved. Nucleic Acids Research 44 (14): 6693-6706 (2016).

2014

Blackledge NP*, Farcas AM*, Kondo T*, King HW, McGouran JF, Hanssen LL, Ito S, Cooper S, Kondo K, Koseki Y, Ishikura T, Long HK, Sheahan TW, Brockdorff N, Kessler BM, Koseki H, and Klose RJ (* co-first author). Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation. Cell 157(6): 1445-1459 (2014).

2013

Long HK*, Sims D*, Heger A, Blackledge NP, Kutter C, Wright M, Grutzner F, OdomDT, Patient R, Ponting CP, and Klose RJ (* co-first author). Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates. eLife 2, e00348 (2013).

  • Insight article in eLife and editors’ choice, eLife

Review : Long HK*, Blackledge NP* and Klose RJ (* co-first author).  ZF-CxxC domain-containing proteins, CpG islands, and the chromatin connection. Biochemical Society Transactions 41, 727-740 (2013).

Farcas AM, Blackledge NP*, Sudbery I*, Long HK*, McGouran JF, Rose NR, Lee S, Sims D, Cerase A, Sheahan TW, Koseki H, Brockdorff N, Ponting CP, Kessler BM and Klose RJ (* co-second author). KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands. eLife 1, e00205 (2012).

  • Editors’ choice, eLife

2012

Blackledge NP*, Long HK*, Zhou JC, Kriaucionis S, Patient RK, Klose RJ (* co-first author). Bio-CAP: A versatile and highly sensitive technique to purify and characterise regions of non-methylated DNA. Nucleic Acids Research 40, e32 (2012).

2011

White RM, Cech J, Ratanasirintrawoot S, Lin CY, Rahl PB, Burke CJ, Langdon E, Tomlinson ML, Mosher J, Kaufman C, Chen F, Long HK, Kramer M, Datta S, Neuberg D, Granter S, Young RA, Morrison S, Wheeler GN, Zon LI. DHODH modulates transcriptional elongation in the neural crest and melanoma. Nature 7339, 518 (2011).